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      INVESTIGACION
  1. Pablo Simón Gaete Pauchard (PhD in Physiological Sciences)
  2. Molecular regulation of the opening dynamics of the pannexin-1-formed channel in endothelial cells: The response triggered by CGRP.


  3. Pannexin-1 (Panx-1) is a membrane protein that form non-selective channels. In the cardiovascular system, Panx-1 is thought to play a physiological role controlling vasomotor
  4. tone and blood pressure. Interestingly, recent evidence shows that prolonged activation of Panx-1-formed channels in the endothelium of resistance arteries in response to the
  5. calcitonin gene-related peptide (CGRP) leads to vascular dysfunction. Notably, the post-translational modifications (PTMs) and the signaling environment that governs the opening of pannexin-1-
  6. formed channels are unknown. Then, my research focuses on: 1) To determine the signaling mechanism that controls the activation of Panx-1 induced by CGRP in endothelial cells,
  7. 2) to assess the structural and functional role of PTMs of panx-1 generated by CGRP and 3) to determine whether CGRP receptor forms signaling microdomains with Panx-1 in endothelial cells.


    8. PROYECTOS


  9. Programa: FONDECYT POSTDOCTORADO
  10. Nº de Proyecto: 3160348
  11. Título: Molecular regulation of the opening dynamics of the pannexin-1-formed channel in endothelial cells: The response triggered by CGRP
  12. Año de Inicio: 2015
  13. Año de Término: 2018


      14. PUBLICACIONES RECIENTES


  14. "Functional role of connexins and pannexins in the interaction between vascular and nervous system". Gaete PS, Lillo MA, Figueroa XF. Journal of Cellular Physiology.
  15. 2014 Oct;229(10):1336-45.

  16. "Diffusion of nitric oxide across cell membranes of the vascular wall requires specific connexin-based channels". Figueroa XF, Lillo MA, Gaete PS, Riquelme MA, Sáez JC.
  17. Neuropharmacology. 2013 Dec;75:471-8.

  18. "Ca2+-activated K+ channels of small and intermediate conductance control eNOS activation through NAD(P)H oxidase" Pablo S. Gaete, Mauricio A. Lillo, Nicolás M. Ardiles,
  19. Francisco R. Pérez and Xavier F. Figueroa. Free Radical Biology & Medicine, 2012, 1;52(5):860-70.


    20. Capítulo de libro:


  20. "Control and coordination of vasomotor tone in the microcirculation" Mauricio A. Lillo, Francisco R. Pérez, Mariela Puebla, Pablo S. Gaete and Xavier F. Figueroa.
  21. The Cardiovascular System - Physiology, Diagnostics and Clinical Implications, David C. Gaze (Ed.), ISBN: 978-953-51-0534-3, InTech Publisher. 2011.
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